CRISPR 相关的产品

Clustered regularly interspaced short palindromic repeats (CRISPRs) and their CRISPR-associated (Cas) proteins constitute the CRISPR-Cas immune system, which provides adaptive immunity against invasive elements such as viruses and plasmids in bacteria and archaea. Cas proteins are endonucleases that use a single guide RNA (sgRNA) to form complementary base pairs with target gene and then cleave the target at specific sites. Due to the programmability, high editing efficiency and ease of use , the CRISPR-Cas systems have emerged as a powerful tool for gene manipulation, with the type II CRISPR-Cas9 system from Streptococcus pyogenes already being widely adopted for various genome-targeting purposes. A distinct group of Cas proteins, including Cas12 and Cas13 among others, possess “collateral cleavage” activity that have been exploited and demonstrated in various diagnostic technologies.


Name Catalog # Source Organism Expression Host Organism Tag Type Sequence
AapCas12b, Active C12B1-E311U Alicyclobacillus acidiphilus E. coli tag-free full length
AsCas12a, Active CS12A-E311H Acidaminococcus sp E. coli His full length
Cas12 (LbCpf1), Active C12CR-E241G Lachnospiraceae E. coli GST full-length
Cas12 (LbCpf1), Active C12CR-E241H Lachnospiraceae E. coli His full-length
CcaCas13b CS13B-E311H Capnocytophaga canimorsus E. coli His full length
EiCsm6, Active CS06-E312H Enterococcus italicus E. coli His full length
EsCas13d ES13D-E31H Eubacterium siraeum E. coli His full length
FnCas12a CF12A-E311H Francisella tularensis E. coli His full length
FnCas12a, Glycerol-Free CF12A-E311HB Francisella tularensis E. coli His full length
LbuCas13a, Active CS13A-E322U Leptotrichia buccalis E. coli tag-free full length
LbuCas13a, Glycerol-Free CS13A-E322UB Leptotrichia buccalis E. coli N/A full length
LsCsm6 LS01-E31H Ligilactobacillus salivarius E. coli His full length
LwCas13a, Active CS13A-E321H Leptotrichia wadei E. coli His full length
PsmCas13b, Active CS13B-E312H Prevotella sp E. coli His full length
SpCas9 (D10A)-NLS CS09N-E331H Streptococcus pyogenes E. coli His full length
SpCas9 (D10A, H840A)-NLS CS09N-E333H Streptococcus pyogenes E. coli His full length
SpCas9 (H840A)-NLS CS09N-E332H Streptococcus pyogenes E. coli His full length
SpCas9, Active CS09-E311H Streptococcus pyogenes E.coli His full length
SpCas9-NLS, Active CS09N-E312H Streptococcus pyogenes E.coli His full length
SpCas9-NLS, Glycerol-free CS09N-E312HB Streptococcus pyogenes E.coli His full length
TccCas13a, Active CS13A-E314H Thermoclostridium caenicola E. coli His full length
TtCsm6, Active CS06-E311H Thermus thermophilus E. coli His full length