主页   >    COVID-19   >   Covid-19 抑制剂

Signalchem Product Image

Captopril

ACE Inhibitor_edited

A51-906
1 g5 g Bulk Customize

*The image is illustrative and does not necessarily represent the product


概述:

**COVID-19 RELATION**
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). The compound is an effective treatment against high blood pressure and a few types of congestive heart failures. SARS-CoV-2 infects the human cells by using its Spike (S) protein to fuse with the human ACE2 cell receptor. Renin-Angiotensin-Aldosterone System Inhibitors such as Captopril are being investigated for their unconventional therapeutic role in inhibiting SARS-CoV-2/ACE2 fusions as a possible treatment option to solve the COVID-19 crisis.**

Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.22 μM) (1). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 &muM for leukotriene B4 formation and Ki = 60 nM for L-lysine-p=nitroanilide) (2). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.


Genebank 编号:

N/A


参考文献:


1. DW Cushman et al. Nat. Med. 1999 5:11102.

2. L Orning et al. J. Biol. Chem. 1991 266:16507

存储稳定性:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


CAS Registry Number:

62571-86-2


Molecular Formula:

C9H15NO3S


Appearance:

White powder


Molecular Weight:

217.3


纯度:

>98% (HPLC, TLC); NMR (conforms)


Solubility:

May be dissolved in DMSO (20 mg/ml) or water (20 mg/ml)


Aliases:

(2S)-1-(3-mercapto-2-methyl-propionyl)-L-proline


Molecular Structure:

Product Element Image



There are no related publications available for this product.

相关产品

Anti-Human IgG Antibody mIgM, Unconjugated , H38-60M
Anti-Human IgM Antibody mIgG, Unconjugated, H38M-60M