MERS Spike Protein RBD

概述:

The Middle East respiratory syndrome coronavirus (MERS-CoV) has caused the MERS outbreak that first originated in Saudi Arabia, but since has spread to other countries around the world (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits (2), S1 and S2, which is known to be the key component to bind with host cells through interaction with dipeptidyl peptidase 4 (DPP4) (3). MERS-CoV can recognize DPP4 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (2).

基因别名:

MERS coronavirus S1, coronavirus S2, coronavirus spike, cov spike, ncov S1, ncov S2, ncov RBD, Spike RBD, RBD

Genebank 编号:

KU696644

配方:

Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 90mM glycine.

参考文献:

1. Mohd H, et al: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir. Viral J. 2016, 13: 87.

2. Lu G, et al: Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 2013, 500: 227-231.

3. Al-Tawfiq et al: Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) Infection. Emerging Infectious Diseases. 2014, 185-190.

Specific Activity :

Binding ability measured in a functional ELISA. DPP4 protein (DP4CD-G40H) can bind to immobilized MERS Spike Protein RBD (MERSD-G241F)

Purity :

Sample Purity Data. For specific information on a given lot, see the related technical datasheet.

Storage, Stability, and Shipping:

Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight :

58 kDa